Publication
So Jisun, Strobel Olivia, Wann Jamie, Kim Kyungchan, Paul Avishek, Acri Dominic J., Dabin Luke C., Kim Jungsu, Roh Hyun Cheol (2024) Robust single nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity. eLife 13:RP97981. https://doi.org/10.7554/eLife.97981.1
Kim K, Wann J, Kim HG, So J, Rosen ED, Roh HC. Uncoupling protein 1-driven Cre (Ucp1-Cre) is expressed in the epithelial cells of mammary glands and various non-adipose tissues. Molecular Metabolism. 2024 Jun;84:101948. doi: 10.1016/j.molmet.2024.101948. Epub 2024 Apr 25. PMID: 38677508; PMCID: PMC11070624.
Basu R, Elmendorf AJ, Lorentz B, Mahler CA, Lazzaro O, App B, Zhou S, Yamamoto Y, Suber M, Wann JC, Roh HC, Sheets PL, Johnson TS, Flak JN. Ventromedial hypothalamic nucleus subset stimulates tissue thermogenesis via preoptic area outputs. Molecular Metabolism. 2024 Jun;84:101951. doi: 10.1016/j.molmet.2024.101951. Epub 2024 May 8. PMID: 38729241; PMCID: PMC11112375.
Kim K, Taleb S, So J, Wann J, Cheol Roh H. Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting. J Vis Exp. 2023 Mar 17;(193). doi: 10.3791/65033. PMID: 37010301.
So J, Taleb S, Wann J, Strobel O, Kim K, Roh HC. Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibility. Molecular Metabolism. 2022 Dec;66:101619. doi: 10.1016/j.molmet.2022.101619. Epub 2022 Oct 21. PMID: 36273781; PMCID: PMC9636484.
Reilly AM, Yan S, Huang M, Abhyankar SD, Conley JM, Bone RN, Stull ND, Horan DJ, Roh HC, Robling AG, Ericsson AC, Dong XC, Evans-Molina C, Ren H. A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues. J Biol Chem. 2022 Jan;298(1):101431. doi: 10.1016/j.jbc.2021.101431. Epub 2021 Nov 18. PMID: 34801552; PMCID: PMC8689209.
Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks AS. Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metabolism. 2020 Oct 6;32(4):665-675
Roh HC, Kumari M, Taleb S, Tenen D, Jacobs C, Lyubetskaya A, Tsai LT, Rosen ED (2020). Adipocytes Fail to Maintain Cellular Identity During Obesity Due to Reduced PPAR𝛾 Activity and Elevated TGFβ-SMAD Signaling. Molecular Metabolism. 42:101086
Roh HC, Tsai LT, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED. Warming induces significant reprogramming of beige, but not brown, adipocyte cellular identity. Cell Metabolism. 2018, 27(5):1121-1137
Shen Y*, Roh HC*, Kumari M, Rosen ED. Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to exogenous steroids, but not insulin resistance caused by high fat feeding. Molecular Metabolism. 2017, 6(10):1150-1160 (*co-first authors)
Roh HC, Tsai LT, Lyubetskaya A, Tenen D, Kumari M, Rosen ED. Simultaneous Transcriptional and Epigenomic Profiling from Specific Cell Types within Heterogeneous Tissues In Vivo. Cell Reports. 2017, 24;18(4):1048-1061
Warnhoff K, Roh HC, Kocsisova Z, Tan CH, Morrison A, Croswell D, Schneider DL, Kornfeld K. The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc. PLoS Biology. 2017, 17;15(1):e2000094
Roh HC, Dimitrov I, Deshmukh K, Zhao G, Warnhoff K, Cabrera D, Tsai W, Kornfeld K. A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans. Nucleic Acids Research. 2015, 43(2):803-16
Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot Jr JJ, Rosen ED, Spiegelman BM. A Smooth Muscle-Like Origin for Beige Adipocytes. Cell Metabolism. 2014, 19(5):810-20
Roh HC, Collier S, Deshmukh K, Guthrie J, Robertson JD, Kornfeld K. ttm-1 Encodes CDF Transporters That Excrete Zinc from Intestinal Cells of C. elegans and Act in a Parallel Negative Feedback Circuit That Promotes Homeostasis. PLoS Genetics. 2013, 9(5): e1003522
Roh HC, Collier S, Guthrie J, Robertson JD, Kornfeld K. Lysosome-Related Organelles in Intestinal Cells are a Zinc Storage Site in C. elegans. Cell Metabolism. 2012, 15(1):88-99
Roh HC*, Yoo DY*, Ko SH, Kim YJ, Kim JM. Bacteroides fragilis Enterotoxin Upregulates Intercellular Adhesion Molecule-1 in Endothelial Cells via an Aldose Reductase-, MAPK-, and NF- κB-Dependent Pathway, Leading to Monocyte Adhesion to Endothelial Cells. Journal of Immunology. 2011, 187(4):1931-41 (*co-first authors)
Kim K, Wann J, Kim HG, So J, Rosen ED, Roh HC. Uncoupling protein 1-driven Cre (Ucp1-Cre) is expressed in the epithelial cells of mammary glands and various non-adipose tissues. Molecular Metabolism. 2024 Jun;84:101948. doi: 10.1016/j.molmet.2024.101948. Epub 2024 Apr 25. PMID: 38677508; PMCID: PMC11070624.
Basu R, Elmendorf AJ, Lorentz B, Mahler CA, Lazzaro O, App B, Zhou S, Yamamoto Y, Suber M, Wann JC, Roh HC, Sheets PL, Johnson TS, Flak JN. Ventromedial hypothalamic nucleus subset stimulates tissue thermogenesis via preoptic area outputs. Molecular Metabolism. 2024 Jun;84:101951. doi: 10.1016/j.molmet.2024.101951. Epub 2024 May 8. PMID: 38729241; PMCID: PMC11112375.
Kim K, Taleb S, So J, Wann J, Cheol Roh H. Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting. J Vis Exp. 2023 Mar 17;(193). doi: 10.3791/65033. PMID: 37010301.
So J, Taleb S, Wann J, Strobel O, Kim K, Roh HC. Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibility. Molecular Metabolism. 2022 Dec;66:101619. doi: 10.1016/j.molmet.2022.101619. Epub 2022 Oct 21. PMID: 36273781; PMCID: PMC9636484.
Reilly AM, Yan S, Huang M, Abhyankar SD, Conley JM, Bone RN, Stull ND, Horan DJ, Roh HC, Robling AG, Ericsson AC, Dong XC, Evans-Molina C, Ren H. A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues. J Biol Chem. 2022 Jan;298(1):101431. doi: 10.1016/j.jbc.2021.101431. Epub 2021 Nov 18. PMID: 34801552; PMCID: PMC8689209.
Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks AS. Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metabolism. 2020 Oct 6;32(4):665-675
Roh HC, Kumari M, Taleb S, Tenen D, Jacobs C, Lyubetskaya A, Tsai LT, Rosen ED (2020). Adipocytes Fail to Maintain Cellular Identity During Obesity Due to Reduced PPAR𝛾 Activity and Elevated TGFβ-SMAD Signaling. Molecular Metabolism. 42:101086
Roh HC, Tsai LT, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED. Warming induces significant reprogramming of beige, but not brown, adipocyte cellular identity. Cell Metabolism. 2018, 27(5):1121-1137
Shen Y*, Roh HC*, Kumari M, Rosen ED. Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to exogenous steroids, but not insulin resistance caused by high fat feeding. Molecular Metabolism. 2017, 6(10):1150-1160 (*co-first authors)
Roh HC, Tsai LT, Lyubetskaya A, Tenen D, Kumari M, Rosen ED. Simultaneous Transcriptional and Epigenomic Profiling from Specific Cell Types within Heterogeneous Tissues In Vivo. Cell Reports. 2017, 24;18(4):1048-1061
Warnhoff K, Roh HC, Kocsisova Z, Tan CH, Morrison A, Croswell D, Schneider DL, Kornfeld K. The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc. PLoS Biology. 2017, 17;15(1):e2000094
Roh HC, Dimitrov I, Deshmukh K, Zhao G, Warnhoff K, Cabrera D, Tsai W, Kornfeld K. A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans. Nucleic Acids Research. 2015, 43(2):803-16
Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot Jr JJ, Rosen ED, Spiegelman BM. A Smooth Muscle-Like Origin for Beige Adipocytes. Cell Metabolism. 2014, 19(5):810-20
Roh HC, Collier S, Deshmukh K, Guthrie J, Robertson JD, Kornfeld K. ttm-1 Encodes CDF Transporters That Excrete Zinc from Intestinal Cells of C. elegans and Act in a Parallel Negative Feedback Circuit That Promotes Homeostasis. PLoS Genetics. 2013, 9(5): e1003522
Roh HC, Collier S, Guthrie J, Robertson JD, Kornfeld K. Lysosome-Related Organelles in Intestinal Cells are a Zinc Storage Site in C. elegans. Cell Metabolism. 2012, 15(1):88-99
Roh HC*, Yoo DY*, Ko SH, Kim YJ, Kim JM. Bacteroides fragilis Enterotoxin Upregulates Intercellular Adhesion Molecule-1 in Endothelial Cells via an Aldose Reductase-, MAPK-, and NF- κB-Dependent Pathway, Leading to Monocyte Adhesion to Endothelial Cells. Journal of Immunology. 2011, 187(4):1931-41 (*co-first authors)
