RESEARCH
We study how to program cellular identity and plasticity to cure metabolic disease
Adipocyte Identity and ReprogrammingAdipocytes play a key role in nutrient and energy homeostasis and come in different flavors: white, brown, beige and more. We are looking for ways to control and reprogram adipocyte identity to improve our metabolic health and cure disease such as obesity and diabetes.
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Cellular Plasticity in Human DiseaseOnce differentiated, somatic cell types maintain cellular identity and fulfill their unique cellular functions, while some cell types have potentials to switch identity. We are exploring how such cellular plasticity contributes to normal physiology in mammals and is implicated in human disease.
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Development of Epigenomic TechniquesWe have established powerful techniques for cell type-specific epigenomic analysis and single cell/nuclei gene expression profiling in vivo. We keep developing new methods that enable us to gain new insights into metabolism research and more.
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